| 100% | LOVELACE | 8 | Surname of the person considered to be the first computer programmer |
| 49% | REM | 3 | Georgia band considered to be one of the first alternative rock groups |
| 49% | BONO | 4 | First musician to be a ''Time'' Person of the Year |
| 48% | DOOM | 4 | First-person shooter game released in 1993 by id Software which is considered to be one of the most influential video games of all time |
| 48% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 48% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 47% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 47% | KIERKEGAARD | 11 | Philosopher often considered to be the first existentialist |
| 47% | LOVELACE | 8 | Considered the first computer programmer, Ada __ |
| 47% | EROICA | 6 | Work some consider to be the first Romantic symphony |
| 46% | JAPAN | 5 | Origin of "The Tale of Genji," considered by many to be the world's first novel |
| 46% | NYAD | 4 | Diana who was the first person to swim from Cuba to Florida without the aid of shark protection (2013) |
| 46% | ADA | 3 | Lovelace considered the first computer programmer |
| 46% | LOVELACE | 8 | Ada __, considered the first computer programmer |
| 46% | TENZINGNORGAY | 13 | Sherpa who was one of the first two people to conquer Mount Everest: 2 wds. |
| 46% | RICHARD | 7 | ___ Rodgers, composer with works like "Oklahoma!' and "The Sound of Music" who was the first person to win the EGOT |
| 45% | MALIK | 5 | Surname of the first member to leave One Direction |
| 45% | GRETATHUNBERG | 13 | First Swedish woman and first person born in the 21st century to be named "Time" magazine's Person of the Year (2 wds.) |
| 45% | CURIE | 5 | Surname of the first woman to win a Nobel prize |
| 45% | EDMUNDHILLARY | 13 | New Zealand mountaineer who was one of the first two people to conquer Mount Everest: 2 wds. |
| 45% | ADA | 3 | Lovelace who has been called the first computer programmer |
| 45% | GIA | 3 | ___ Carangi, considered to be the world's first supermodel |
| 44% | WAR | 3 | What truth is said to be the first casualty of |
| 44% | HAMMURABI | 9 | Babylonian King, said to be the first set of laws |
| 44% | IVANI | 5 | Person who built the first stone Cathedral of the Archangel in Moscow and was also the first person to be buried there |
| 44% | EROICA | 6 | Work considered by some to be the first Romantic-era symphony |
| 44% | HORTA | 5 | Victor —, Belgian architect considered to be the originator of Art Nouveau |
| 43% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 43% | ADA | 3 | ___ Lovelace, 19th century English mathematician who was regarded the first computer programmer |
| 43% | MONEY | 5 | "___ for Nothing," 1985 hit by Dire Straits which was one of the first music videos to feature computer-animated human figures |