| 100% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 84% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 79% | PETERCAPALDI | 12 | Twelfth actor to play the lead role in 15-Across, starting in 2013: 2 wds. |
| 57% | RODDYPIPER | 10 | Rowdy ___, a wrestler who went on to play the lead role in the cult classic "They Live": 2 wds. |
| 54% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 51% | MARKWAHLBERG | 12 | Actor from "The Italian Job", who plays the lead role of Cade Yeager in 30-Across : 2 wds. |
| 51% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 50% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 50% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 49% | RUSSELLCROWE | 12 | "Gladiator" actor who plays the title role in the 2010 film "Robin Hood" (2 wds.) |
| 49% | HENRYFONDA | 10 | "On Golden Pond" actor who played the title role in 32-Across: 2 wds. |
| 49% | TOMELLIS | 8 | Actor who plays the titular role in the fantasy series "Lucifer": 2 wds. |
| 48% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 47% | KITHARINGTON | 12 | "Pompeii" lead actor, who plays the role of Jon Snow in "Game Of Thrones" : 2 wds. |
| 47% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 47% | RUSSELLCROWE | 12 | He played the title role in 2010's "Robin Hood": 2 wds. |
| 47% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 47% | JASONROBARDS | 12 | Actor who played 15-Across in the 1967 film "The St. Valentine's Day Massacre": 2 wds. |
| 46% | MATTHEWRHYS | 11 | "The Americans" actor who plays the title role in HBO's "Perry Mason": 2 wds. |
| 45% | ZACEFRON | 8 | Actor who plays a protégé of 15-Across in "The Greatest Showman": 2 wds. |
| 45% | TOPHERGRACE | 11 | Actor who played the role of Eric Forman in the TV show "That '70s Show": 2 wds. |
| 45% | MICHAELKEATON | 13 | "Mr. Mom" actor who played the title role in 40-Across (2 wds.) |
| 44% | BRYANCRANSTON | 13 | American actor who played the lead in "Breaking Bad" and also starred in "Malcolm in the Middle": 2 wds. |
| 44% | JOSHBROLIN | 10 | Actor who plays the fixer in 18-Across: 2 wds. |
| 44% | DAVIDTENNANT | 12 | Actor who played the Tenth Doctor in "Doctor Who" (2 wds.) |
| 44% | HARRISONFORD | 12 | Second actor to play the CIA operative played by Chris Pine in "Jack Ryan: Shadow Recruit" (2 wds.) |
| 43% | SAMROCKWELL | 11 | Actor who plays the father in the 2015 remake of 18-Across: 2 wds. |
| 43% | SPENCERTRACY | 12 | Actor who played the lawyer based on Clarence Darrow in 32-Across: 2 wds. |
| 43% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 43% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |