| 100% | GRIFFINS | 8 | The ___, "Family Guy" family helmed by Peter and Lois, featuring their children Meg, Chris, and Stewie |
| 56% | SMITHS | 6 | The ___, "American Dad!" family helmed by Stan and Francine, featuring their children Hayley and Steve |
| 56% | MARSHES | 7 | The ___, "South Park" family helmed by Randy and Sharon, featuring their children Stan and Shelley |
| 49% | PICKLES | 7 | The ___, family from the namesake show helmed by Stu and Didi, featuring their children Dil and Tommy |
| 49% | JETSONS | 7 | The ___, family from the namesake show helmed by George and Jane, featuring their children Judy and Elroy |
| 40% | LOIS | 4 | ___ Griffin, mom to Meg, Chris, and Stewie on the animated TV series "Family Guy" |
| 37% | SIS | 3 | Meg, to Chris and Stewie, on "Family Guy" |
| 37% | LOIS | 4 | Meg, Chris, and Stewie's mom, on "Family Guy" |
| 36% | LOIS | 4 | Chris, Meg, and Stewie's mother, on "Family Guy" |
| 34% | STEWIE | 6 | Peter and Lois' youngest son in Family Guy |
| 31% | BLONDIE | 7 | Comic strip featuring the Bumsteads and their children, Alexander and Cookie |
| 31% | THUNDERBIRDS | 12 | 1960s ITV puppet series featuring the Tracy family devised by Sylvia and Gerry Anderson |
| 31% | MEG | 3 | Chris and Stewie's sister on "Family Guy" |
| 31% | MEG | 3 | Peter and Lois's daughter on "Family Guy" |
| 31% | THEFAMOUSFIVE | 13 | Series of children's novels written by Enid Blyton featuring the adventures of a group of young children and their dog Timmy: 3 wds. |
| 31% | FOXTROT | 7 | Comic strip featuring Andy and Roger, and their children, Peter, Paige and Jason |
| 30% | BABYBLUES | 9 | Comic strip featuring the MacPhersons and their children, Zoe, Hammie, and Wren (2 wds.) |
| 30% | MEG | 3 | ___, Chris, and Stewie, animated siblings from "Family Guy" |
| 29% | HIANDLOIS | 9 | Comic strip featuring the Flagstons and their children, Chip, Dot, Ditto, and Trixie (3 wds.) |
| 29% | SON | 3 | Chris or Stewie, to Peter Griffin on "Family Guy" |
| 28% | DEARTHEODOSIA | 13 | “Hamilton” duet sung by Burr and Hamilton to their children |
| 27% | THEBORROWERS | 12 | & 15A 1959 children’s book by Mary Norton; third in a series featuring the Clock family |
| 27% | GUYSWITHKIDS | 12 | A TV series co-created and written by Jimmy Fallon, chronicling the lives of three friends and their children: 3 wds. |
| 27% | PETER | 5 | Husband of Lois and father of Stewie on "Family Guy" |
| 27% | CAMPTIGER | 9 | Children's book by 52-Across and illustrator John Rocco that features a big cat in the woods (2 wds.) |
| 27% | PETERGRIFFIN | 12 | Cartoon dad of Meg, Chris, and Stewie (2 wds.) |
| 26% | ADDAMS | 6 | Last name of the TV family headed by Morticia and Gomez |
| 26% | STATIONWAGON | 12 | Family car largely replaced by the minivan and SUV |