| 100% | FRY | 3 | The main character in "Futurama" |
| 84% | MACAW | 5 | The main character in "Rio" is one |
| 83% | EMOTIONS | 8 | The main characters in “Inside Out,” e.g. |
| 82% | TEDMOSBY | 8 | The main character in How I Met Your Mother |
| 82% | SALESMEN | 8 | The main characters in "Glengarry Glen Ross," by trade |
| 81% | CHANCE | 6 | Christopher, the main character in Human Target |
| 81% | GAY | 3 | Like the main characters in "Fire Island" |
| 81% | PROSPERO | 8 | Main character in The Tempest |
| 81% | BELLA | 5 | ___ Swan, the main character in the "Twilight" series |
| 81% | JUNGLE | 6 | Mowgli is the main character in The __ Book |
| 81% | RAIDER | 6 | Lara Croft is the main character in Tomb __ |
| 80% | ASH | 3 | Main character in the "Pokémon" series |
| 80% | OHARA | 5 | Scarlett ___, the main character in "Gone with the Wind" |
| 80% | CHARLIE | 7 | With 47-Across, the main character in 15-Across |
| 80% | SKYWALKER | 9 | Last name of the main character in Star Wars |
| 80% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 80% | CROMWELL | 8 | Thomas, the main character in Mantel's Wolf Hall |
| 79% | MDS | 3 | Most of the main characters in "Private Practice": Abbr. |
| 79% | CARMY | 5 | Main character in TV series The Bear |
| 79% | OFFRED | 6 | Main character in The Handmaid's Tale |
| 79% | PROSPERO | 8 | Main character in Shakespeare's The Tempest |
| 79% | FBI | 3 | Org. for the main character in the 2024 movie Longlegs |
| 79% | OLAF | 4 | Count ___, the main character in "A Series of Unfortunate Events" |
| 78% | ELSA | 4 | Main character in the upcoming movie "Frozen 2" |
| 78% | HERO | 4 | The main character or protagonist in a novel |
| 78% | EPISODEONE | 10 | The main characters are usually introduced in it |
| 78% | DOM | 3 | First name of the main character in the "Fast & Furious" movies |
| 78% | BABE | 4 | Little pig who's the main character in two 1990s movies |
| 78% | OYL | 3 | Olive ___ who was the main character in "Thimble Theatre" before Popeye |
| 78% | RON | 3 | Weasley, one of the main characters in the "Harry Potter" series |