| 100% | LIV | 3 | The main character on "iZombie" |
| 85% | HOMER | 5 | The main character on "The Simpsons" |
| 81% | LIV | 3 | Nickname of the main character on "Scandal" |
| 81% | TEENS | 5 | The main characters on Netflix's "Heartbreak High," e.g. |
| 80% | TONY | 4 | First name of the main character on "The Sopranos" |
| 80% | DON | 3 | Draper who's the main character on "Mad Men" |
| 80% | LUC | 3 | Jean-___ (first name of the main character on "Picard") |
| 79% | CARTMAN | 7 | Eric ___, one of the main characters on "South Park" |
| 79% | DRS | 3 | All the main characters on "Grey's Anatomy" (Abbr.) |
| 79% | ZACK | 4 | Main character on “Saved by the Bell” |
| 79% | HANK | 4 | Main character on "King of the Hill" |
| 71% | WALTONGOGGINS | 13 | "Justified" actor who plays the main character Wade on 18-Across: 2 wds. |
| 69% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 65% | ISABELSANFORD | 13 | Actress who played Louise Jefferson, the main character on the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 65% | RUE | 3 | Main character on "Euphoria" |
| 64% | FRY | 3 | The main character in "Futurama" |
| 63% | LARRY | 5 | Main character on "Curb Your Enthusiasm" |
| 63% | SAM | 3 | Main character on "Dear White People" |
| 62% | WALT | 4 | Main character on "Breaking Bad," for short |
| 62% | OTIS | 4 | Main character on Netflix's "Sex Education" |
| 62% | MACAW | 5 | The main character in "Rio" is one |
| 62% | CALTECH | 7 | Nickname of the school where the main characters on "The Big Bang Theory" worked |
| 61% | LARACROFT | 9 | The main character of the Tomb Raider games |
| 61% | TED | 3 | Main character on "How I Met Your Mother" |
| 61% | HERO | 4 | The main character or protagonist in a novel |
| 61% | EPISODEONE | 10 | The main characters are usually introduced in it |
| 61% | RANGEBEDFELLOWS | 15 | The main characters of "Brokeback Mountain," e.g.? |
| 61% | EMOTIONS | 8 | The main characters in “Inside Out,” e.g. |
| 61% | SAL | 3 | One the main character's from Jack Kerouac's "On the Road", not Dean Moriarty |
| 61% | RAPUNZEL | 8 | __ is the main character of Tangled |