| 100% | SALESMEN | 8 | The main characters in "Glengarry Glen Ross," by trade |
| 48% | FRY | 3 | The main character in "Futurama" |
| 48% | DANNY | 5 | ___ Zuko, main character played by John Travolta in the 1978 film "Grease" |
| 48% | SANDY | 5 | ___ Olsson, main character played by Olivia Newton-John in the 1978 film "Grease" |
| 47% | MACAW | 5 | The main character in "Rio" is one |
| 47% | EMOTIONS | 8 | The main characters in “Inside Out,” e.g. |
| 46% | TEDMOSBY | 8 | The main character in How I Met Your Mother |
| 46% | GAY | 3 | Like the main characters in "Fire Island" |
| 46% | CHANCE | 6 | Christopher, the main character in Human Target |
| 46% | PROSPERO | 8 | Main character in The Tempest |
| 45% | ALECBALDWIN | 11 | Actor who made a cameo in "Glengarry Glen Ross" by playing the role of Blake, the guy who is sent to motivate the sales team: 2 wds. |
| 45% | BELLA | 5 | ___ Swan, the main character in the "Twilight" series |
| 45% | JUNGLE | 6 | Mowgli is the main character in The __ Book |
| 45% | RAIDER | 6 | Lara Croft is the main character in Tomb __ |
| 45% | ASH | 3 | Main character in the "Pokémon" series |
| 45% | MDS | 3 | Most of the main characters in "Private Practice": Abbr. |
| 45% | OHARA | 5 | Scarlett ___, the main character in "Gone with the Wind" |
| 45% | CHARLIE | 7 | With 47-Across, the main character in 15-Across |
| 45% | SKYWALKER | 9 | Last name of the main character in Star Wars |
| 45% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 45% | CROMWELL | 8 | Thomas, the main character in Mantel's Wolf Hall |
| 45% | OFFRED | 6 | Main character in The Handmaid's Tale |
| 45% | PROSPERO | 8 | Main character in Shakespeare's The Tempest |
| 45% | CARMY | 5 | Main character in TV series The Bear |
| 44% | FBI | 3 | Org. for the main character in the 2024 movie Longlegs |
| 44% | OLAF | 4 | Count ___, the main character in "A Series of Unfortunate Events" |
| 44% | EPISODEONE | 10 | The main characters are usually introduced in it |
| 44% | ELIO | 4 | Main character in "Call Me by Your Name" |
| 44% | ELSA | 4 | Main character in the upcoming movie "Frozen 2" |
| 44% | HERO | 4 | The main character or protagonist in a novel |