| 100% | EMOTIONS | 8 | The main characters in “Inside Out,” e.g. |
| 66% | ONEL | 4 | Main character in "The Paper Chase," e.g. |
| 61% | RANGEBEDFELLOWS | 15 | The main characters of "Brokeback Mountain," e.g.? |
| 58% | FRY | 3 | The main character in "Futurama" |
| 58% | TEENS | 5 | The main characters on Netflix's "Heartbreak High," e.g. |
| 57% | TROUPE | 6 | The main characters of the film “The Travelling Players,” e.g. |
| 57% | MACAW | 5 | The main character in "Rio" is one |
| 56% | CONMAN | 6 | Either main character in "Dirty Rotten Scoundrels," e.g. (2 wds.) |
| 55% | SALESMEN | 8 | The main characters in "Glengarry Glen Ross," by trade |
| 55% | TEDMOSBY | 8 | The main character in How I Met Your Mother |
| 55% | GAY | 3 | Like the main characters in "Fire Island" |
| 55% | DISGUST | 7 | Mindy Kaling's character in Inside Out |
| 55% | CHANCE | 6 | Christopher, the main character in Human Target |
| 55% | PROSPERO | 8 | Main character in The Tempest |
| 55% | BELLA | 5 | ___ Swan, the main character in the "Twilight" series |
| 55% | JUNGLE | 6 | Mowgli is the main character in The __ Book |
| 55% | RAIDER | 6 | Lara Croft is the main character in Tomb __ |
| 54% | ASH | 3 | Main character in the "Pokémon" series |
| 54% | MDS | 3 | Most of the main characters in "Private Practice": Abbr. |
| 54% | OHARA | 5 | Scarlett ___, the main character in "Gone with the Wind" |
| 54% | CHARLIE | 7 | With 47-Across, the main character in 15-Across |
| 54% | SKYWALKER | 9 | Last name of the main character in Star Wars |
| 54% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 54% | CROMWELL | 8 | Thomas, the main character in Mantel's Wolf Hall |
| 54% | OFFRED | 6 | Main character in The Handmaid's Tale |
| 54% | PROSPERO | 8 | Main character in Shakespeare's The Tempest |
| 54% | CARMY | 5 | Main character in TV series The Bear |
| 53% | FBI | 3 | Org. for the main character in the 2024 movie Longlegs |
| 53% | OLAF | 4 | Count ___, the main character in "A Series of Unfortunate Events" |
| 53% | EPISODEONE | 10 | The main characters are usually introduced in it |