| 100% | PIEPAN | 6 | Tin tossed as the first Frisbee |
| 45% | OPEN | 4 | Serve as the first act |
| 45% | TOIL | 4 | Sweat as the first lubricant |
| 45% | PETER | 5 | Saint recognized as the first Pope |
| 45% | SOUP | 4 | Liquid served as the first course |
| 44% | PERICLES | 8 | Known as the first citizen of Athens |
| 44% | ADA | 3 | Lovelace, recognized as the first computer programmer |
| 44% | ADALOVELACE | 11 | Mathematician regarded as the first computer programmer |
| 44% | ANTED | 5 | Tossed in the first chip |
| 44% | WELTERS | 7 | Tosses, as the sea |
| 43% | ELLA | 4 | Fitzgerald known as the First Lady of Song |
| 43% | ASONANT | 7 | Not voiced, as the first "d" in "Wednesday" |
| 42% | ELLAFITZGERALD | 14 | Music legend known as the First Lady of Song |
| 42% | ADALOVELACE | 11 | Nineteenth-century mathematician regarded as the first computer programmer |
| 42% | ADA | 3 | ___ Lovelace, mathematician often regarded as the first computer programmer |
| 42% | PLYMOUTH | 8 | Site of what many regard as the first Thanksgiving |
| 42% | QUAD | 4 | Where college kids toss the frisbee |
| 41% | EVITA | 5 | 1997 6-Across starring Madonna as the first lady of Argentina |
| 41% | EBSEN | 5 | Whom Haley replaced as the Tin Woodman |
| 40% | ASTOR | 5 | Nancy who served as the first female member of the British Parliament |
| 40% | LILITH | 6 | Female demon of Jewish folklore depicted as the first wife of Adam |
| 40% | PERSIAN | 7 | The first Iraq war was known as the __ Gulf War |
| 40% | PREMIERED | 9 | Had the first showing (of), as a film |
| 40% | WARMUPPITCH | 11 | Preparatory toss before the first inning |
| 40% | ADAM | 4 | First man as per the bible |
| 40% | ONSET | 5 | First appearance, as of the flu |
| 40% | PARTI | 5 | First installment, as of The Godfather |
| 40% | TOMMY | 5 | CBS series featuring Edie Falco as the first woman LAPD chief of police |
| 40% | MOTIF | 5 | Recurring phrase, such as the first four notes of Beethoven’s Fifth Symphony |
| 40% | LETCHWORTH | 10 | Town in Hertfordshire founded in 1903 as the first garden city in England |