| 100% | STARGATE | 8 | Titular portal in a sci-fi show |
| 65% | GALACTICA | 9 | Titular ship in a sci-fi series |
| 59% | ROLLERBALL | 10 | Titular sport in a 1975 dystopian sci-fi film |
| 53% | LOST | 4 | "___ in Space," sci-fi show about space that is a futuristic take on "Swiss Family Robinson" |
| 51% | THINGS | 6 | "Stranger ___," sci-fi show starring Millie Bobby Brown that follows a group of friends in the '80s |
| 51% | APES | 4 | Captors in a sci-fi classic |
| 51% | EMPATH | 6 | Feeler in a sci-fi novel |
| 51% | UFO | 3 | Craft in a sci-fi movie |
| 51% | LEIA | 4 | Princess in a sci-fi classic |
| 50% | UFO | 3 | Ship in a sci-fi story: Abbr. |
| 50% | TEK | 3 | Drug in a sci-fi novel series |
| 50% | HUMANRACE | 9 | "Our" side in a sci-fi battle |
| 50% | TEK | 3 | Drug in a sci-fi Shatner novel |
| 50% | ROBOT | 5 | Android in a sci-fi movie, say |
| 50% | APE | 3 | Caesar, in a sci-fi movie franchise |
| 50% | HANSOLO | 7 | Killer of Greedo in a sci-fi film |
| 50% | UFO | 3 | Spacecraft in a sci-fi movie, sometimes: Abbr. |
| 50% | APES | 4 | Heston's jailors, in a sci-fi film |
| 50% | APE | 3 | Dr. Cornelius, in a sci-fi film series |
| 50% | NEO | 3 | "The One," in a sci-fi film series |
| 49% | MOONBASE | 8 | Lunar outpost in a sci-fi story: 2 wds. |
| 49% | OBIWAN | 6 | Real name of Ben, in a sci-fi classic |
| 49% | ALIENRACE | 9 | Side opposite 41-Across in a sci-fi clash |
| 49% | UFO | 3 | Flying saucer in a sci-fi movie, perhaps: Abbr. |
| 49% | UFO | 3 | Space vehicle in a sci-fi film, perhaps: Abbr. |
| 49% | UFO | 3 | Alien spacecraft in a sci-fi film, say: Abbr. |
| 48% | IMPLANT | 7 | Microchip in a sci-fi character's brain, e.g. |
| 48% | MACE | 4 | Windu played by Samuel L. Jackson in a sci-fi franchise |
| 47% | BLACKMIRROR | 11 | Sci-fi show with a "Bandersnatch" spinoff |
| 47% | ALIENROMUL | 10 | 2024 installment in a sci-fi/horror franchise that climaxes with [SPOILER] |