| 100% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 66% | SHELDON | 7 | Who Amy marries in The Big Bang Theory |
| 61% | BIALIK | 6 | Mayim who played Amy in The Big Bang Theory |
| 60% | NERDY | 5 | Like most characters in The Big Bang Theory |
| 60% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 59% | GALECKI | 7 | Johnny __ plays Leonard in The Big Bang Theory |
| 59% | YLEM | 4 | Matter in the Big Bang theory |
| 59% | WIL | 3 | Wheaton who plays himself on The Big Bang Theory |
| 58% | RAJ | 3 | "The Big Bang Theory" character who was born in New Delhi |
| 57% | BAZINGA | 7 | Sheldon word for "gotcha" in The Big Bang Theory |
| 57% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 56% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |
| 55% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 55% | AMY | 3 | ___ Farrah Fowler, neuroscientist from "The Big Bang Theory" who has a Ph.D. in Neurobiology |
| 54% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 53% | WIL | 3 | Actor Wheaton who's guest-starred on "The Big Bang Theory" |
| 53% | WIL | 3 | Actor Wheaton who occasionally guest-stars on "The Big Bang Theory" |
| 52% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 52% | WIL | 3 | Wheaton who played himself on "The Big Bang Theory" |
| 51% | RAJ | 3 | Only "The Big Bang Theory" friend who is unmarried when the series ends |
| 51% | PARSONS | 7 | "The Big Bang Theory" star Jim |
| 51% | JIM | 3 | "The Big Bang Theory" star Parsons |
| 51% | RAJ | 3 | Indian in "The Big Bang Theory" |
| 50% | ATOM | 4 | Symbol in "The Big Bang Theory" logo |
| 50% | LEONARD | 7 | "The Big Bang Theory" friend who married Penny |
| 50% | ARMITAGE | 8 | Child actor Iain who plays the title role in "The Big Bang Theory" spin-off "Young Sheldon" |
| 50% | JIMPARSONS | 10 | Star of "The Big Bang Theory": 2 wds. |
| 50% | AMY | 3 | Sheldon's girlfriend in "The Big Bang Theory" |
| 50% | LEONARD | 7 | Penny's husband in "The Big Bang Theory" |
| 50% | GEEKS | 5 | Many characters in "The Big Bang Theory" |