| 100% | JERRYSEINFELD | 13 | "Comedians in Cars Getting Coffee" host who plays a Kellogg's employee in 48-Across (2 wds.) |
| 65% | JERRYSEINFELD | 13 | "Comedians in Cars Getting Coffee" host who had a 2017 self-titled Netflix comedy special: 2 wds. |
| 51% | TIGNOTARO | 9 | Comedian who plays a radio host in the Amazon series "One Mississippi": 2 wds. |
| 48% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 47% | PHOEBECATES | 11 | Actress who plays a bank employee whose boyfriend gets a monstrous Christmas gift in "Gremlins" (2 wds.) |
| 45% | JERRY | 5 | ___ Seinfeld who hosts "Comedians in Cars Getting Coffee" |
| 44% | QUINTABRUNSON | 13 | "A Black Lady Sketch Show" comedian who created and plays a second grade teacher in "Abbott Elementary": 2 wds. |
| 43% | RUPAULCHARLES | 13 | "Drag Race" host who got a Hollywood Walk of Fame star in March 2018: 2 wds. |
| 43% | CHARLIEDAY | 10 | "It's Always Sunny in Philadelphia" actor who plays a detective in 15-Across: 2 wds. |
| 43% | PIPERLAURIE | 11 | "Carrie" actress who played 27-Across's mother in "Children of a Lesser God": 2 wds. |
| 43% | JOHNNYDEPP | 10 | Actor who played a vampire in 2012's "Dark Shadows": 2 wds. |
| 43% | BILLYBOB | 8 | With 48-Across, "Bad Santa" star who played a serial killer on FX's "Fargo": 2 wds. |
| 43% | DREWCAREY | 9 | "The Price Is Right" host who once lived in a car: 2 wds. |
| 43% | HARVEYKORMAN | 12 | Costar of 39-Across who played a villain in "Blazing Saddles": 2 wds. |
| 42% | CRISTINMILIOTI | 14 | Actress who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 42% | ANDYSAMBERG | 11 | Actor who plays a wedding guest who's stuck in a time loop in 44-Across: 2 wds. |
| 42% | MARLEEMATLIN | 12 | "CODA" actress who played a deaf employee at the school in "Children of a Lesser God": 2 wds. |
| 42% | BRADLEYCOOPER | 13 | "Silver Linings Playbook" actor who played 48-Across's love interest in 33-Across: 2 wds. |
| 42% | HUGHGRANT | 9 | "Love Actually" actor who plays a Shakespearean actor cast to voice Tony the Tiger in 48-Across (2 wds.) |
| 42% | GARYOLDMAN | 10 | "The Dark Knight" actor who plays a dictator in "The Hitman's Bodyguard": 2 wds. |
| 42% | OTFAGBENLE | 10 | "The Handmaid's Tale" actor who plays a S.H.I.E.L.D. agent in 39-Across (2 wds.) |
| 42% | SAMROCKWELL | 11 | "Iron Man 2" actor who played a kidnapped tech genius in "Charlie's Angels": 2 wds. |
| 42% | FARRAHFAWCETT | 13 | "Charlie's Angels" actress who played a photographer nicknamed Beauty in "The Cannonball Run": 2 wds. |
| 41% | GENEWILDER | 10 | Actor who played 31-/34-Across in a 1971 film: 2 wds. |
| 41% | JOHNNYDEPP | 10 | Actor who played 31-/34-Across in a 2005 film: 2 wds. |
| 41% | KARYNPARSONS | 12 | Actress who played the snobbish cousin of 17-Across in "The Fresh Prince of Bel-Air," which is rumored to be getting a reunion: 2 wds. |
| 41% | CAREYMULLIGAN | 13 | "The Great Gatsby" actress who plays a feminist in 42-Across: 2 wds. |
| 41% | MERYLSTREEP | 11 | "Into the Woods" actress who plays a feminist in 42-Across: 2 wds. |
| 41% | CHRISEVANS | 10 | "Avengers: Endgame" actor who plays a cult leader in 15-Across: 2 wds. |
| 41% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |