| 100% | WINONARYDER | 11 | "Heathers" actress who played Lydia in 40-Across (2 wds.) |
| 72% | WINONARYDER | 11 | "Stranger Things" actress who plays Lydia Deetz in "Beetlejuice Beetlejuice": 2 wds. |
| 69% | WINONARYDER | 11 | Actress who played Lydia Deetz in the 1988 film "Beetlejuice" and Joyce Byers on "Stranger Things" in 2019: 2 wds. |
| 68% | MAYARUDOLPH | 11 | "Bridesmaids" actress who plays Christine in 32-Across: 2 wds. |
| 66% | DAKOTAFANNING | 13 | "The Twilight Saga" actress who plays Sara Howard in 40-Across (2 wds.) |
| 66% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 66% | RACHELZEGLER | 12 | Actress who plays Maria in 30-Across (2 wds.) |
| 66% | ARIANADEBOSE | 12 | Actress who plays Anita in 30-Across (2 wds.) |
| 66% | MAUDEAPATOW | 11 | "This Is 40" actress who plays 30-Across's sister in "The King of Staten Island": 2 wds. |
| 65% | MIREILLEENOS | 12 | "The Killing" actress who plays Marissa in 33-Across: 2 wds. |
| 65% | JULIANNEMOORE | 13 | "Still Alice" actress who plays 19-Across later in life: 2 wds. |
| 64% | SANDRADEE | 9 | Actress who played Gidget in 1959: 2 wds. |
| 64% | BETTEMIDLER | 11 | "Beaches" actress who played witch Winnie Sanderson in 29-/30-Across: 2 wds. |
| 64% | ANYATAYLORJOY | 13 | "Glass" actress who played 19-Across in a 2020 film: 2 wds., hyph. |
| 64% | LEAMICHELE | 10 | Actress who plays 17-Across' girlfriend and was 29-Across' girlfriend in real life: 2 wds. |
| 64% | KATHYNAJIMY | 11 | "Sister Act" actress who played witch Mary Sanderson in 29-/30-Across: 2 wds. |
| 64% | JENNIFERLOPEZ | 13 | "Hustlers" actress who played US marshal Karen Sisco in 23-/35-Across: 2 wds. |
| 63% | WINONARYDER | 11 | Actress who played Lydia Deetz and now plays Joyce Byers: 2 wds. |
| 63% | JACKIWEAVER | 11 | "Silver Linings Playbook" actress who plays Sandy in 32-Across: 2 wds. |
| 63% | OLIVIAMUNN | 10 | Actress who plays Psylocke in "X-Men: Apocalypse": 2 wds. |
| 63% | KRYSTENRITTER | 13 | Actress who plays Jessica Jones in "The Defenders": 2 wds. |
| 63% | JOANCUSACK | 10 | Actress who plays Jessie in "Toy Story 4": 2 wds. |
| 63% | HAYLEYATWELL | 12 | "Agent Carter" actress who plays 18-Across's wife Evelyn in "Christopher Robin": 2 wds. |
| 63% | MARYJ | 5 | With 40-Across, "The Wiz Live!" actress who plays Florence in "Mudbound": 2 wds. |
| 63% | MANDYPATINKIN | 13 | "Homeland" actor who plays Irwin in 40-Across (2 wds.) |
| 63% | JANETLEIGH | 10 | Actress who played Marion Crane in "Psycho": 2 wds. |
| 63% | AMYADAMS | 8 | Actress who played Lynne Cheney in "Vice": 2 wds. |
| 63% | CHARLIZETHERON | 14 | Actress who plays Megyn Kelly in "Bombshell": 2 wds. |
| 63% | NICOLEKIDMAN | 12 | Actress who plays Gretchen Carlson in "Bombshell": 2 wds. |
| 63% | LISAKUDROW | 10 | Actress who plays Phoebe Buffay in "Friends": 2 wds. |