| 100% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 53% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 48% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 45% | ANGELAMERKEL | 12 | German chancellor who earned a doctoral degree in quantum chemistry from the German Academy of Sciences: 2 wds. |
| 45% | ANNAKENDRICK | 12 | Actress who had a song from "Pitch Perfect" chart on the Billboard Hot 100 in 2013: 2 wds. |
| 45% | ANNEHATHAWAY | 12 | Actress who had a song from "Les Misérables" chart on the Billboard Hot 100 in 2013: 2 wds. |
| 43% | ADAMWEST | 8 | Batman actor from the 1960s who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 41% | DIANELANE | 9 | "Unfaithful" actress who plays Penny Chenery, the owner of 33-Across, in a 2010 film (2 wds.) |
| 41% | SHAQUILLEONEAL | 14 | Basketball great who earned a doctoral degree in human resource development from Barry University: 2 wds. |
| 40% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 40% | JERYLPRESCOTT | 13 | Actress who plays Madame Xanadu, a blind fortune teller, in the show in 18a: 2 wds. |
| 40% | JANECURTIN | 10 | Actress who played Prymaat from the planet Remulak in 1993's "Coneheads": 2 wds. |
| 40% | SANDRABULLOCK | 13 | "The Blind Side" actress who played a crossword constructor in 33-Across: 2 wds. |
| 40% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 40% | MAYIM | 5 | ___ Bialik, Emmy-nominated actress best known for her role in "The Big Bang Theory" who has a degree in Neuroscience |
| 39% | AMY | 3 | ___ Farrah Fowler, neuroscientist from "The Big Bang Theory" who has a Ph.D. in Neurobiology |
| 39% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 39% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 39% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 39% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 39% | ZOESALDANA | 10 | Actress who played Gamora from the planet Zen-Whoberi in 2014's "Guardians of the Galaxy": 2 wds. |
| 39% | MINDYKALING | 11 | "The Office" actress who owns a stake in the Swansea City Association Football Club: 2 wds. |
| 39% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel about one of the scientists as a boy (2 wds.) |
| 39% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 39% | DIANEKEATON | 11 | Actress who plays a mother in "Father of the Bride" (2 wds.) |
| 38% | LAURIEMETCALF | 13 | "The Big Bang Theory" actress whose daughter portrays her character's younger self on "Young Sheldon": 2 wds. |
| 38% | EMMATHOMPSON | 12 | "Howards End" actress who returns as a doctor in "Bridget Jones: Mad About the Boy": 2 wds. |
| 38% | ALISTROKER | 10 | Actress who won a Tony for her role as Ado Annie in the 2019 Broadway revival of "Oklahoma!": 2 wds. |
| 38% | KRISTENWIIG | 11 | "Bridesmaids" actress who voices Brenda, a hot dog bun, in the animated series "Sausage Party: Foodtopia": 2 wds. |
| 38% | INGRIDBERGMAN | 13 | "Casablanca" actress who played a Swedish missionary in "Murder on the Orient Express": 2 wds. |